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Epigenetics (as in "epigenetic landscape") was coined by C. H. Waddington in 1942 as a portmanteau of the words genetics and epigenesis.[5] Epigenesis is an old[6] word that has more recently been exapted (see preformationism for historical background) to describe the differentiation of cells from their initial totipotent state in embryonic development. When Waddington coined the
The study of heritable changes in gene function that occur without a change in the DNA sequence.